Hi James and PMO DCN,
From a support standpoint, we do NOT support the cluster itself, however you can install our products in a cluster environment. Service Desk is what we call "cluster tolerant" but it is NOT "cluster aware" - meaning, we can be installed in a cluster environment, but we are not aware of the cluster and do not act based upon the status of cluster nodes. Thus there is no automatic way of failing over seamlessly. As for the SQL side, when you failover a SQL cluster, there will be a disconnection that occurs, which can affect Service Desk depending on how long that takes to complete. We have had some customers recently that made a switch to complete solid-state storage for their SQL clusters, and the failover takes mere fractions of a second, and they are able to do it without affecing the product at all. In a traditional storage environment, many customers end up having to recycle service desk services to get the connection to the db re-established. Now, as for Advanced Availability (called AA as James mentioned) - it does offer high availability for the application, but the best advantage of it in my opinion is the performance increase due to the fact that in an AA environment, each app server has its own virtual-database process, and its own db agents, allowing for much more efficient query returns from the db than the conventional architecture in which all db transactions are done through the primary server only. So the AA architecture will cut out a lot of excess communication between servers, allowing for much better performance. I agree with James that clustering should really only be a last resort as it wont really offer you much in regards to high availability within the product itself. Failing over the Service Desk application server wont be seemless, and will require manual intervention.
For info about the Advanced Availability architecture, take a look at the wiki site here: Installation Considerations - CA Service Management - 14.1 - CA Technologies Documentation
Hope this helps,
Jon Israel
Principal Support Engineer
CA Technologies