I'm still trying to pinpoint the issue and possibly resolve it by myself. Can you share more info, for example how much work do you do in your VM?
I am interestingly also running latest Linux Mint as Guest OS. I am using the VM for heavy software development, and after a working session (8 - 10 hours) the VM is borderline unusable. GUI is unresponsible, le't say 5 - 10 fps, and interestingly opening files is extremely slow. GUI responsiveness is gradually worse the more I use the VM.
Host is mostly unaffected by this, with the exception of sound. When I am listening something on the host and make guest "sweat" with opening files or fast scrolling, the sound starts to crack and skip.
When I had this issue for the first time, I was actually buyning completely new PC. Clean Windows 10 host, different SSD (same vendor, Samsung), different GPU (same vendor, Nvidia), different CPU (different vendor, AMD). The VM acted the same, so for me the only common things are host OS version, Nvidia driver and guest OS. The issue was resolved for half a year and started again, either by Nvidia driver update or upgrade to Workstation 16, unfortunately I cannot pinpoint it more precisely.
It's just my feeling, but it seems, that working with files inside Guest OS is responsible for the issue. I newly installed Ubuntu as a fresh VM just to see if Linux Mint is part of the problem, but after a while of basic usage, I see that the flicker appears again (as a first sign of a responsiveness failure).