I can tell you from my experience (I also have a thread relating to this which is un-answered) that if you wish to use CCR in vSphere then you DO need to set up a shared storage (often refered to as a Quorom) disk.
I guess what would help answer the question is what OS are you thinking of using in yoru cluster? If you use 2008 you can use a File Share Witness which in theory removes the need of the Quorom disk but in reality doesnt (or at least when I've tried to get the darned thing working).
I'd love to know how you go.