Hi
As Weinstein says, usually this behavior appears when the ESX is performing CPU contention. From your screen shots seems to be some high values of CPU Ready.
What's the configuration of the other box? is it critical also? What i will try is:
1.- IF second VM is not critical, power it off...and see how perform the critical one.
2.- Modify shares and give more shares to the critical box: in case of fight it will get the resources.
3.- Monitor deeply the ESX with the esxtop and check the %rdy value also....and the other CPU values to see any problem.
Regards
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