Can you find any evidence of the connection succeeding at some point? For instance, does it fail 4 or 5 times and then succeed, and only reappear during a restart? If so, check your host firewalls and make sure that port 80 is open and accepts traffic from the replication appliance/server. We had an issue where port 80 was blocked and it was causing a delay in the HBR http service starting up - thus the connection would fail (connection refused) a few times and then eventually succeed once the services started. We would only have the problem during startup. Double check other necessary ports on the host as well.
There is also an internal VMware KB article that apparently deals with an SSL issue. Apparently updating the SSL certificate on the appliance can cause a similar problem. Steps for resolution are as follows:
Open an SSH session to the VRMS server and run these commands:
1. Change directory to /opt/vmware/etc/lighttpd using this command:
cd /opt/vmware/etc/lighttpd
2. Run this command to obtain the new SSL thumbprint:
openssl x509 -in server.pem -noout -fingerprint
3. Manually update the HMS thumbprint in the HBR database using the command:
hbrsrv-guestinfo.sh set guestinfo.hbr.hms-thumbprint 'new thumbprint value'
4. Restart HBR server process using the command:
/etc/init.d/hbrsrv restart
5. Review the HMS logs to verify the errors cease
6. You may also need to restart the HMS server process on the ESXi hosts (/etc/init.d/hms restart) to update the new HBR SSL thumbprint.
Anyway - hope that helps someone as I could find very little else on the problem. Make sure you follow VMware SSL guidelines when creating the certs as that can cause a plethora of issues as well.