Do you feel there is any performance loss running the RAID5 as a vmfs?
Keep in mind if performance is your goal, then you should consider making the entire disk array RAID 5. Those 2 spindles you are losing as RAID 1 will do no good, since ESX doesn't use any DISK IO, it's a VM host, so it's not running anything.
So I would make those 2 disks a part of the RAID 5 configuration, install ESX across ALL the drives, and it will create the remainder free space as VMFS.
Spindle count is key when it comes to VM performance. The more disk spindles the better.