Yes, jumbo frames are enabled. I have 4 gb nics on the host and 4 on the NAS. All IP'd separately. Multipathing is also enabled and functioning. It's a Synology DS1815+ with 8 Western Digital 5tb Red Pro drives.
*Edit - I also dropped the IOPS Round Robin limit down to 1 which helped a little in overall performance but has not addressed this issue.