Hi Ken...
A couple of questions that may help me answer you. What OS and Version of GroupWise are you currently running? At 25 users I am assuming one or two domains(two good for fault tolerance) one Post Office, one Internet gateway(gwia) and perhaps WebAccess. ow big is the Post office in disk storage space???? This is the most important issue. It will determine what type of disk to create.
Is this server doing anything else other than GroupWise? If It's only GroupWise any particular reason for using an OES 11 server and not just straight SLES 11?
Without some specifics about the system, # of messages it handles daily, disk space for the PO. I would say that this system would not require a lot of resources. I'd start with a System with 1 CPU and 6 GB of ram. VMFS5 has good enough performance for your disk storage , though my preference is to use an external datastore, so that the VM can be migrated to another host quickly.
Hope that helps.
Paul Lamontagne
Lamtech Consulting Inc.
Co-Author of The Caledonia Upgrade Guide for GroupWise 2014
http://www.caledonia.net/