If this was an election, I'd vote for Josh26 :smileywink:
Just some additions to his recomendation:
vSwitch0:
2 pNICs connected to trunk ports on the pSwitch (vmnic0, vmnic1)
Service Console Portgroup - VLANxxx - (vmnic0 active, vmnic1 standby)
VMkernel Portgroup for vMotion - VLANyyy - (vmnic0 standby, vmnic1 active)
Virtual Machine Network - VLANzzz - (vmnic0 active, vmnic1 standby)
vSwitch1:
2 pNICs (vmnic2, vmnic3)
VMkKernel Portgroup for iSCSI
With the above configuration you separated iSCSI traffic, which is most important.
SC and VM network share one pNIC and vMotion has it's dedicated pNIC.
Everything is redundant.
André