With an additional NIC with 2 ports a general setup could look something like this:
vSwitch0 - vmnic0, vmnic1 (each connected to different physical switches)
VMkernel Management network
VMkernel vMotion network (own IP network, own VLAN)
Best if these are setup as active/standby.
vSwitch1 - vmnic2, vmnic3 (each connected to different physical switches)
VM portgroups
vSwitch2 - vmnic4, vmnic5 (each connected to different physical switches)
VMkernel iSCSI (own IP network, own VLAN)
Best if this is added to the iSCSI Multipath component, which is quite easy in vSphere 5.