Sure. There're several steps to follow:
1. Dump the EDID binary
You can use the Monitor Asset Manager tool. Run the tool and the list of monitor connected will be listed on the left side, select the monitor and then click File --> save, save the EDID as .bin file.
Monitor Asset Manager tool is available at: http://www.entechtaiwan.com/util/moninfo.shtm
2. Confirm the Connector
Run command prompt as Administrator, then run emulateEDID.exe without any parameter;
All connectable “Connector ID” is listed. As shown in the figure below, the number 0-9 is DisplayID. DP, DVI and HDMI connections are shown is Digital; VGA is shown as VGA.
DisplayID is calculated by Windows and there's no pattern. You may need to check each time you run this tool.
In this example, 2 Dell 2312HM and one HP LA2306 are connected.

3. Once you know the DisplayID, type this command:
emulateEDID.exe <ConnectorID> <EDID file>
For example, if you have saved the EDID of HP LA2306 as la2306.bin, you need to run
emulateEDID.exe 4 la2306.bin
emulateEDID.exe 5 la2306.bin
Please note both digital and analog port should be "emulated"
Reboot the system to let the change take effect. After the emulation, an HP LA3206 monitor will be detected no matter it’s really connected.
4. If you need to restore hot plug detection on this port, just run the tool with connection ID and no other parameters, for example:
emulateEDID.exe 5
Now with emulated EDID and choose PCoIP protocol in connection server, you're fine to go!
Just use View Client to connect to your VM and choose the emulated Monitor as primary.
Use AMD Catalyst Control Center to disable the secondary monitor.
You can run dxdiag to check if AMD graphic is used.