Are you able to connect to the host using vsphere client ?
If you are not able to, then it clearly states that the hostd agent of the server is not responding. That is the very reason it is seen as not responding in vcenter.
You can try browsing the datastores from ssh if it gets stuck at the prompt then that is the reason for the hang of hostd agent.
If the host is seeing any storage related issue or any hangs in the network then the host would get into a not responding state.
you can review the vmkernel logs then it should tell us the reason for the hostd hang.
--Nitin