There is absolutely, beyond the shadow of a doubt, a significant difference in network performance when Fault Tolerance is enabled.
We are currently testing a FT File Server on which we are utilizing folder redirection (My Docs/Desktop/etc). A few of us noticed some things running sluggishly after migrating to this FT file server over the previous non-FT file server. There is minimal load on this file server, as only a test bed of 4 users are accessing this server via Folder Redirection (or anything else, for that matter).
For me, I noticed slowness with an application that is just an executable on my desktop. Dragging the window around was severely sluggish. For my co-worker, he noticed the search in the Windows Start Menu was very slow (typing in the name of an application vs. finding it in a list).
Since FT can be enabled/disabled on the fly, we disabled FT, and ...you guessed it...night and day difference.
This article gives a visualization of the difference in speed (showing also what my coworker was doing with typing in the name of an application in the start menu):
Visualizing the Impact of Folder Redirection – Start Menu Search • Helge Klein
Fault Tolerance is set up properly, and behaves exactly as it should (tested failovers, duplicated files in secondary datastore, etc.) with this lagginess exception.
As for our environment, it's the fastest I've ever had the pleasure in which to work: 100% SSD Fiber Channel SAN (Pure Storage), 20GB FlexFabric network connections with dual-vMotion configuration.
We are currently running vCenter 6.0 U2 with ESXi U2 (vCenter 6.0.0 b3634794, ESXi 6.0.0 b3620759), so the latest for both at the time of this publication.
Note the final sentence in this article (also copied here after the link).
Fault Tolerance Performance in vSphere 6 - VMware VROOM! Blog - VMware Blogs
Testing shows that vSphere FT can successfully protect a number of workloads like CPU-bound workloads, I/O-bound workloads, servers, and complex database workloads; however, admins should not use vSphere FT to protect highly latency-sensitive applications like voice-over-IP (VOIP) or high-frequency trading (HFT).
Although one would expect to take at least some hit by enabling FT, the difference we are seeing is leading us to seek other HA options.