Hi,
Some more details about hardware and VMware environment would have been nice.
Check the status of hostd and vpxa service. Try re-starting them. Check the host.log and vpxa.log to see if there is any error.
If you don't find anything useful in there, you can also check vmkernel.log, vmkwarning.log and vobd.log at /var/run/log location.
Do check if any ESXi host partition is showing 100% full through df -h command. If any is showing full, consider emptying it a bit and then re-start management services.
Make sure you are re-starting management services in off business hours.