We had the same problem and have a new working situation now.
Haven't figured out the exact cause yet, but is has to do with a misconfiguration of the netsacler software in combination with delivery controllers/subnets/ network and/or arp requests.
Works as designed (which I think was wrong in the first place)
Ik took us 3 days to solve.
Yes we did the vmware update and had the same issue. Bring the network interfaces up and down, you have a ping and suddenly the netscaler stops responding. And on the console we were not able to ping any gateway or external server. But we had 100+ other vmservers with no problems. And yes it looked like this was our only freebsd based server, and yes our only netscaler server. So why did that one only have the problem.
I think the software thinks it has a new route based on an incoming packet from a citrix delivery controller and decides on it's own to change the default route to an other interface (not sure yet which one the Nsip/vip/mip/snip or whatever)
We got the latest netscaler software, buildt it on our XEN hypervisor environment got it working. And after a few hours we got a similar problem. In this case the ip adresses were still pingable but the result was the same. No access.
In the netscaler virtual server STA ticketing authority interface we had 4 controllers 2 down and 2 up. The ones that were up were on a different subnet than the one that were down.
The up ones were our latest added delivery controllers. They were in the same ip-subnet as the NSIP interface.
So we removed them rebooted the netscaler and the problem was solved.
My concusion (for now) the STA must not be in the same subnet as the NSIP (and /or) the 2 VIP's we had. Our MIP was in allreadyin a different subnet.
Now I'm trying the figure out with our external party who installed out netscaler appliance 2 years ago what the requirements are for all the different interfaces and subnets/vi/STA etc within the netscaler software.
And I think it was pure luck the pasted 2 yearsk that the vmware hosts probably blocked that uninteded network trafic/arp requests or whatever.
When the smoke clears we will try to install it back on the vm platform and see if we get it working again
Forgive my typos etc, I'm in a hurry (lost 3days not puzzling ;-)
Cheers and have a nice weekend.
Eric Burger