IMHO is an interesting question,
In vCenter 7.0U3C when creating a new virtual machine and adding a VMXNET3 network adapter, as stated by , it did select by default the DirectPath I/O option. I beg your pardone, but if it's a bug in the vCenter GUI interface, then is not resolved.
Beside doing apparently nothing I also dig on the web about this option but also I have not found any clear indication on Vm impact performance.
Well, a "lab" obviously is not a production environment but I tend to approxymate it as much as possible, eventually replicanting useful thing on the "real world".
Regards.