A datacenter is a logical grouping of hosts
"A virtual datacenter is a container for all the inventory objects required to complete a fully functional environment for operating virtual machines. You can create multiple datacenters to organize sets of environments. For example, you might create a datacenter for each organizational unit in your enterprise or create some datacenters for high performance environments and others for less demanding virtual machines."
If you're not using HA or DRS, then you just create a datacenter and then add hosts. For HA/DRS you need a cluster, but first have to create datacenter.