Depends on the features you are planning to use. For a default installation with 4 NICs (Management, vMotion/DRS, VM traffic) I'd probably use two uplinks (one to each physical switch) for Management and vMotion and the other two uplinks for Virtual Machine traffic. vSwitches configured with the default policy "Route based on originating port ID". All uplinks configured as trunk (802.1Q) ports.
as an example:
vSwitch0 - vmnic0, vmnic2 (both active)
--> Management Port Group - Management VLAN with vmnic0 active and vmnic2 standby
--> vMotion Port Group - vMotion VLAN with vmnic0 standby and vmnic2 active
vSwitch1 - vmnic1, vmnic3 (both active)
--> Virtual Machine Port Groups with appropriate VLANs configured and all vmnics active
This may be different in case you are going to use e.g. FT which requires it's own vmnic.
André