Can you explain a bit how come you have four NUMA nodes with just 2 CPUs ?
Are these some kind of Opteron CPUs ?
As I understand this setting you don't need to change it when you increase the amount of vCPUs.
This setting is for defining the minimum number of cores above which vSphere kernel will start to create additional vNUMA nodes
With the default setting = 8, when your VM has 8 cores it will have just 1 vNUMA node and vNUMA autosizer will set your VM on 1 socket with 8 cores.
If your VM will have 10 cores, then it will have 2 vNUMA nodes and vNUMA autosizer will set it on 2 sockets with 5 cores.
Why it does not matter in your case:
1. The default setting seems to be aligned with your physical NUMA size -> 2 CPU * 16 cores / 4 NUMA nodes = 8 cores
2. If you have CPU settings manually defined, the vNUMA autosizer does not intervene, and this setting is not used
3. If you want to increase the vCPU above 16, you may need to look for amount cores divided by 3. It looks like you are going into VM that will utilize 3 physical NUMA nodes.
You may want to check this fling for further results:
Virtual Machine Compute Optimizer | VMware Flings
Please bear in mind that it has somewhat limited support for more exotic NUMA environments