basically your only options are as follow:
a: RDM of 4TB (not too sure if that is fully supported. I think it is not)
b: Dedicated 4TB iSCSI target mounted in the Guest OS using the Guest OS's software iSCSI initiator
c: multiple VMDKs, mounted into the OS and formated with the builtin software raid or as LVM if linux.
pick one. all have their own querks and foibles.