Having the same issue, from playing around a bit it is either a weird coincidence or it's related to the number of metrics coming in to the TIM. When we increase the number of metrics and restart the TIM it connects and runs for awhile then connection errors occur.
Have noticed the error changes, sometimes it's the Setdomain*.xml or settime or another, but the setdomain and setime are the 2 most common occurring.
Is this similar to your issue? and do you see these errors too?
May 8, 2013 10:07:43 AM SAST
Enterprise Manager cannot reach TIM
Communications
Enterprise Manager
10.*.*.*
Error retrieving
http://10.*.*.* wily/cem/tim/mod_python/timfiles/initBTstats?beforeDate=1368000097: Read timed out
May 8, 2013 10:46:26 AM SAST
Limit exceeded adding new components
Processing
Enterprise Manager
10.*.*.*
Limit exceeded adding new components to
Will be logging a call with CA about this, will update you with any feedback they have.