Hi Joel,
I checked our internal sources and could not find anything on Office 365 being yet possible with APM itself because it is in the MS Azure cloud.
In 10.7 we have Azure support for .NET applications but it won't help for this.
It seems it has been done in the past with an CA ASM monitor and also for an Android based use with CA AXA
Hope that is of some help.
(Converting to discussion for others to provide input)
Regards,
Lynn