Actually, it depends on what kind of multi-factor you want. CA SSO has always supported several strong authentication/multi-factor authentication mechanisms:
X.509 Client Certificate Plus Forms,
SecureID
SafeCard
If by "multi-factor", you mean HTLM Forms plus One-Time-Password, then the answer is no, it is not currently supported by SiteMinder as a built-in-feature.
Someone submitted a OTP solution to the CA Experts forum recently, but I don't think that forum is open to the public, so you would probably have to get someone at CA to make it available to you. Also, it is not supported by CA so it would be up to you to implement it without support. But here is the link: https://communities.ca.com/docs/DOC-231171278?et=watches.email.document
In the past the CA Services Global Deployment team has offered an extra-cost pre-built PWP that implemented OTP, but it is not currently available as a standard offering. CA Services Global Deployment is the team that Ujwol referred to above. We develop tailored solutions for customers and also offer some standard solutions.
CA SSO does provide a publicly available software development kit that includes an API that can be used to develop tailored authentication schemes that plug into the CA SSO policy server. The SDK kit includes a sample auth scheme, but the sample does not do OTP or any kind of multi-factor/strong authentication. Also, it takes a fairly advanced JAVA or C++ developer who has extensive CA SSO experience, or is willing to do very detailed study of the CA SSO documentation, to develop an authentication scheme.
If you describe exactly what features you are looking for in a multi-factor authentication mechanism then a more specific response could be provided to you.
Rick