Hi Monika,
both uxpurge and on-the-fly-purge (AKA continuous purge, handled by the Launcher) are indeed replaced by the new online purge (composed of a dynamic purge performed by the Launcher and of a non-dynamic purge performed cyclically by the IO server) as of release V5.3.3 of Dollar Universe.
Parameters regarding on-the-fly-purge in the uxsetenv* and *.def files should be commented or deleted, but only for the sake of clarity, as when you activate the new online purge (by setting variable U_IO_PURGE_ENABLE to Y and defining the u_purge_param.ref file), the existing settings of the on-the-fly-purge are ignored. I would recommend to comment them though
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uxpurge should not be executed any more.
So you should replace uxpurge and on-the-fly-purge by the new online purge (IO_PURGE as you call it).
As usual, I would recommend to test the change in a test environment before going live.
Michel