Don't know about no effiency modes ...
... but I just tried on a Win11 24H2 machine how different OS'ses run. There is a separate thread for that ... when it gets approved.
On a Windows 10 client, VMware installed with NO VBS Mode Host, and using standard Microsoft Windows computers (both Host and Client), Side Channel Midigations disabled ... a rather OpenGL graphics and database intensive standalone application works just fine. VMware version is 17.5.2.