Hi,
vSphere Replication requires vCenter to function so you can't use VR to protect it as you wouldn't have a way of recovering it, unless it was replicated to another vCenter (in which case it could be recovered, but only inside of the other vCenter) or if it was managed by another vCenter.
If you're looking at the second option, where you have a management vCenter and VR appliance, and within that you have another vCenter, then yes, you could use SRM in this model to protect and failback your internal vCenter.
No difference in this functionality between vCA and windows version of vCenter.
Regarding your statement: "or is it like AD/SQL/Exchange and in general you shouldn't be using replication or anything of the sort for them."
- vSphere Replication supports VSS quiescing
- I agree I wouldn't recommend replicating AD (or SQL and Exchange if you can use the built in application level replication)
- If you can't though, most modern applications work fine in a crash consistent state (normal VR replication) and the remainder work with VSS
Hope this answers your questions