Yes, VMware has VMware VSAN that is "storage virtualization software that, when combined with vSphere, allows you to manage compute and storage with a single platform."
Here is a link to the course that covers VMware VSAN deploy and manage processes. VMware vSAN: Deploy and Manage [V6.7]
Eventually, there are many 3rd party tools used with VMware vSphere/ESXi as S2D alternatives. Some of them are EMC Unity VSA, Starwind Virtual SAN, and HPE StorageVirtual VSA. The following pages describe the solutions and their pros and cons. Either one does shared-nothing storage to the cluster. They differ on requirements, licensing and performance.
Or would the best route be to pass how ever many disks to a Windows VM and have the VM handle it?
What are you trying to set up? As it asked, please elaborate a bit more on your VMware case.