Hi,
vSphere is only capable to handle LUNs of 2 TB (-512B), but a datastore could be build out of multiple LUNs.
If your datastore is 3.4 TB large, then you're using at least 2 LUNs.
Your question couldn't be really answered, as it depends on several different things.
More LUN's are better to handle an higher IO load than a single LUN, but an extended datastore is configured as a concatenated filesystem.
But this doesn't mean that using an extended datastore is a bad thing when it comes to performance.
When you create VM's on such a datastore, VMware does have a mechanisum to spread the VM's on different LUN's building that datastore.
So in fact it's neither striped nor concatenated.
Hope this helps a bit.
Greetings from Germany. (CET)