I will attempt to increase the block size.
You can't. Switching to another block size would require to recreate/reformat the datastore!
Since you mentioned the VM is ~2TB in size the issue may be related to the maximum supported disk size in order to be able to create snapshots. In the KB article posted by Grzesiekk you can find a table at the end of the article ("Calculating the overhead required by snapshot files") which lists the maximum disk sizes based on block sizes (btw. for ESXi 5.0 with VMFS-5, only the last line applies)
Since snapshots are sparse files, the additional space is needed for metadata.
André