To give some feedback...
ESX Server v 3.5
I created a FC LUN on my IBM DS4800 SAN.
I mapped that to the HBA on the box that was going to host the ESX server.
I installed Vmware ESX server (HPDL385 G2 2 dual core opteron 12 GB ram) on the local server disks.
I installed Windows Server 2008 R2 as a VM. During the VM setup I had a choice for RDM. I selected this and immediately could see the LUN on the SAN.
So the Windows VM installed on the SAN.
I then created another LUN on the SAN to add another hard drive to the Windows Server.
To get the Windows VM to see the new LUN, I downed the VM. Rescanned the FC HBA on the ESX server on storage adapters/configuration TAB (right click adapter and rescan).
I then went to the VM settings and added a new hard drive as an RDM. It could immediately see the new LUN.
I started the Windows VM up again and there was the new hard drive.
Very easy and user friendly.