I'm curious about your use case. If you take 12 x 4 TB drives = 48 TB per node x 64 nodes (Max in a vSAN 6 cluster) = 3,072 TB. I mean wow! What are you scaling to 3 Petabytes?
One doesn't need to scale to 64 nodes to want high storage density.Any time someone asks about VSAN, storage density per socket becomes an issue. That's $2.5K per socket and some customers aren't willing to drop down to a single socket per host, meaning $5K/host in VSAN licensing. Since external storage expansion doesn't seem to be supported despite GA announcements, VSAN starts looking like a capacity license.
2U 24 disk SFF host:
3 disk groups of 7 HDD + 1 SDD
The largest SFF HDD on the HCL is 1.2TB, so
24 * 1.2TB = 28.8TB/host
Using 6TB LFF drives:
12 * 6TB = 72TB/host
That's 2.5x the storage per VSAN socket license.
With Dell's FX2 architecture, you can get three FD322 storage modules with 5 x 7 SFF drive disk groups.
35 * 1.2TB = 42TB
6TB drives are still 1.7x the storage per VSAN socket license.
If you're willing to go larger than 2U, the HP SL4540 will scale to 60 LFF drives, so you can reach the 35 drive/host VSAN limit. The Cisco C160 scales to 60 LFF drives, but it's controller isn't on the VSAN HCL.
HP seems to have the best capability to scale VSAN, with the SL4540, 35 LFF drives, and a controller and 6TB SAS drives on the HCL. And even then, the largest HP SDD on the VSAN HCL is 1.6TB, when you should have 2.1TB per 42TB disk group.
I smell a blog post coming on.