Thank you for your answer. Maybe you can tell me your Workflow. So I can adapt mine. Well, as you already said, I also have a multi-screen Desktop Machine. Honestly with 4 Screens attached and one is an ultra-wide. So I have enough desktop Space. And the machine is also quite powerful. 16 Cores / 128GB RAM.
My current setup is, that I have VMware open on one Screen. And here I use it as a "normal" machine with just one screen. Just like I would do it with a remote machine connected via RDP.
One of the Problems I run into, is to switch in between Windows with Alt-Tab. Sure I can switch into the VM, but then Alt-Tab is used in the VM itself. Yes, I can press Ctr+Alt ant then Alt+Tab, but it's uncomfortable and slows down the workflow.