Hi,
Please go through the link below ..It might help you in resolving this issue.
http://service1.symantec.com/SUPPORT/ent-security.nsf/docid/2008101309471148
"Unable to connect to the server specified" error during the replication of Symantec Endpoint Protection Manager
Question/Issue:
In this document the "source Manager" will be the Symantec Endpoint Protection Manager (SEPM) connected to the database that is to be replicated and "destination Manager" the Symantec Endpoint Protection Manager whose database will be created as a replication of the source Manager Database. After a Replication Partner is added the error "Unable to connect to the server specified" occurs. There may be other errors.
Symptoms:
The following errors occur:
Error "Unable to connect to the server specified" during the first replication on the destination Manager, while trying to add the replication partner via the Management Server Configuration Wizard. After this error the destination Manager installation is damaged due to the database replication failure.
Error "Retrieval of local changed data for replication requested by remote server x.x.x.x failed during retrieving data! [reason: Failed to retrieve Metadata - Java heap space]" in Admin > Server > Notification Area of the source Manager.
Error "java.lang.OutOfMemoryError: Java heap space" in the scm-server-0.log of the source Manager.
Cause:
The Symantec Endpoint Protection Manager is a Java-based application much of it's performance is related to the size of the "Java Heap". Modifying the settings that control the size of the Java Heap will improve the performance of a wide variety of the functions performed by the Symantec Endpoint Protection Manager.
Solution:
To adjust the Symantec Endpoint Protection Manager heap size:
Click Start> Run.
In the Run dialog box, type regedit
Press Enter.
Locate the following registry key:
HKLM\SYSTEM\CurrentControlSet\Services\semsrv\Parameters\
Locate the following keys:
JVM Option Number 0
JVM Option Number 1
Adjust the key values upward, and for optimal performance, match the key values.
For example, to create a 1 GB static heap, set: "JVM Option Number 0" to "-Xms512m", and set "JVM Option Number 1" to "-Xmx1024m".
Close Regedit.
Click Start> Settings> Control Panel> Administrative Tools
In the Services dialog box, right-click Symantec Endpoint Protection Manager, and then click Restart.