When we go in Start -> Run type mstsc by default mstsc.exe file present in system32 is called. We want to block access of that file. We have create a application control but it is not working.
So you want to prevent people from using Microsoft's Remote Desktop Application? You may want to double check your steps against this document.
How to configure Application Control in Symantec Endpoint Protection 11.0 : Configuring Application Control Policies
http://www.symantec.com/docs/TECH102525
Bear in mind, Application and Device Control Policies do not work on 64-bit client computers.
sandra