Check the contents of the location path:
C:\Documents and Settings\All Users\Application Data\Symantec\SyKnAppS
You should find the following files & folders:
Folders
Freezer
LiveUpdate
Updates
Files
patch25.dll
SyKnApps.dll
SyKnApps.grd
SyKnApps.sig
SyKnApps.spm
cohcol.grd
cohcol.sig
cohcol.wlt
cal.grd
cal.sig
cal.wlt
If any of the above files/folder in the SyKnAppS folder are missing, then this should be replaced from a computer where PTP is updating definitions.
Make sure that the SEP service is stopped before replacing.
Replace missing files
Start SEP service again
Start > Run > Services.msc > Symantec Endpoint Protection Service
Reboot the SEP client.
SEP client should show the latest PTP definition date and should continue updating