Are you using Asset Management? If not, read on...if yes, it could be a little tricky...
The original machine (once it gets a new HD) won't have the same name as the original one, so it will get a different GUID when it is built and named. NS generates the GUIDs (and ensures uniqueness) based on a name.domain combination (myComputer.MyDomain), assuming you are using AD and importing from AD or other domain discovery.
So if you really want to reset the GUID, you would be to delete the existing computer object on the NS, then use the /resetGuid to get a new one from the client (or re-run your AD / Network discovery to cause a new one to be generated). When the machine sends its basic inventory (myComputer.MyDomain), the NS will look it up, not find that key, and generate a new GUID and give it to the machine.
But like I said, this isn't really necessary. When the original chassis gets a new drive installed and is built with a new name, it will get its own GUID.