With unmanaged clients, you will not have an option to simply turn off or allow this signature.
The quick and dirty fix is to right click the SEP icon in the task tray and "Disable Symantec Endpoint Protection" when using Skype:
This effectively disables the Firewall and IPS and will allow all traffic/IPS signatures. If you are OK with this, I would recommend going that route.
If not, you can try creating an exception for Skype within the firewall policy.
Open the SEP client and and click Options to the right of NTP and select Configure Firewall Rules
Select Add
On the General tab add in your rule name, Allow this traffic, and leave the rest at the default:
Switch to Applications tab, click Browse navigate to the directory where Skype is installed and exclude the proper process(s). Sorry I don't have Skype installed so I couldn't show it in the screenshot but you get the point :-)
Now, move the Skype Allow rule to the top and click OK:
See if that fixes it.
If it doesn't try adding the Skype directory as a Centralized Exception
HTH,
Brian