Thanks for all your responses. Below are a couple lines of the Solidifier logging. Most of the denied acces seems to be around ccSvcHst.exe. I'll whitelist that one and then test. Thanks again.
ERROR: evt.c : 1216: McAfee Solidifier prevented unauthorized execution of 'C:\Documents and Settings\All Users\Application Data\Symantec\Symantec Endpoint Protection\12.1.671.4971.105\Data\Definitions\VirusDefs\20140212.033\ECMSVR32.DLL' by process C:\Program Files\Symantec\Symantec Endpoint Protection\12.1.671.4971.105\Bin\ccSvcHst.exe (Process Id: 1780, User: NT AUTHORITY\SYSTEM).
SYSTEM: cctl_kern.c : 1470: Process '\Device\HarddiskVolume1\Program Files\Symantec\Symantec Endpoint Protection\12.1.671.4971.105\Bin\ccSvcHst.exe' tried to launch '\Device\HarddiskVolume1\Documents and Settings\All Users\Application Data\Symantec\Symantec Endpoint Protection\12.1.671.4971.105\Data\Definitions\VirusDefs\20140212.033\ECMSVR32.DLL' which has been DENIED EXECED. Exec perms = 0
ERROR: evt.c : 1216: McAfee Solidifier prevented unauthorized execution of 'C:\Documents and Settings\All Users\Application Data\Symantec\Symantec Endpoint Protection\12.1.671.4971.105\Data\Definitions\IPSDefs\20140213.001\IDSxpx86.dll' by process C:\Program Files\Symantec\Symantec Endpoint Protection\12.1.671.4971.105\Bin\ccSvcHst.exe (Process Id: 1780, User: NT AUTHORITY\SYSTEM).