My machines are on XP Pro SP3, using SAV10.
A couple of weeks ago I started getting profile issues, too (c0000218, etc). Sometimes people would log into temp profiles without warning, and not be able to change any settings. Video sometimes would be default VGA but trying to change it wouldn't do anything (users report "Big icons"). Sometimes they can't find their default printer or default email account in Outlook Express.
If I can login in normal mode, I schedule a CHKDSK /F and uninstall SAV10. After reboot, login is immediately OK. I then reinstall SAV10 and everything is fine. So far disk error reports have been a mixed bag. Chkdsk is either finding nothing or minor inconsistencies. Even if you do chkdsk, and find no problem, you still have to uninstall SAV10 and reinstall.
Its primarily happening on desktops, a variety of Intel based boards D945s and D101s (about 75). I have Toshiba tablets (about 40+ M7x0 series) and they have all been fine so far.
I have even had a few home users call asking what's going on.
I feel like this is a real problem. I hope Symantec will check it out.