Hello,
I completely agree with Posthums.
The definition files on a client get corrupt. They will continually try to grab the Full.zip file containing all defs from the SEP server.
However, personally I would see few things here.
a) What version of SEPM and SEP are they on?
b) Any GUP's on the Network?
I would then also recommend tring Rolling back of the definitions by the following the steps below and check if that works.
1) Login to the Symantec Endpoint Protection Manager
2) Click on Policies
3) Click on Liveupdate
4) On the Right Hand side, click on the Liveupdate Content TAB
5) Double click on the Liveupdate Content Policy.
6) Click on Security Definitions
7) Click on the Bullet Button that states Select Version
8) Click on Edit and
9) Click on the Drop Down arrow and Select the Right previous versions of Definitions.
10) Click on OK