Hello,
Yes, SEP 12.1 RU2 version will work on Server 2012
SEP 12.1 RU2 is the earliest supported build which is compatable with Windows 8 and Server 2012.
Symantec Endpoint Protection 12.1 RU2 (SEP 12.1.2015) now supports additional new platforms and configurations.
You can now install Symantec Endpoint Protection Manager on the following operating systems:
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Windows 8
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Windows Server 2012
Check these Articles:
What's new in Symantec Endpoint Protection 12.1.2
http://www.symantec.com/docs/HOWTO81091
About Windows 8 and Symantec Endpoint Protection 12.1
http://www.symantec.com/docs/TECH174348
Latest Symantec Endpoint Protection Releases - SEP 12.1 RU2 and SEP 11.0 RU7 MP3
www-secure.symantec.com/connect/articles/latest-symantec-endpoint-protection-releases-sep-121-ru2-and-sep-110-ru7-mp3
Best practices for upgrading to Symantec Endpoint Protection 12.1.2
http://www.symantec.com/docs/TECH163700
Downloadable Guides in reference to the Symantec Endpoint Protection 12.1 RU2
https://www-secure.symantec.com/connect/downloads/downloadable-guides-reference-symantec-endpoint-protection-121-ru2
Hope that helps!!