SEP 12.16. MP1 and later supports Windows 10.
http://www.symantec.com/docs/INFO2746
Please check the following:
Does pinging the remote computer returns the correct IP address? (If not there is an issue in DNS)
Is the remote computer is in a domain or workgroup?
Are you using a domian sdministration cred to authenticate the deployment? (If not try using one)