Hello Arpit,
I can echo what Matt is saying about stale content leaving sessions open. I would also check the existing connections and verify that something like streaming content didn't sneek its way in. While it's rare, I have seen that happen because the CPL needed to be tweaked.
Also, I have run into situations where the connection table is being oversaturated and its causing the CAS to fail in communication with the Proxy. When troubleshooting we would systematically shut down tabs, and turning off the DLP integration resolved the issue. It helped us narrow down the issue when we had to involve Support.
Either was this leads to ICAP messages for the end users (which is what I assume you are seeing). If you see high counts in the Duration column it might be worth investing what that content is and whether it needs to be added to a bypass or blocked.
Large durations and small Sizes usually mean a hung session.
Just curious if this is still occurring or not.
Regards,
Perry