Could you please elaborate on your issue?
What happens when you are replicating? Do you receive any errors?
Could you please provide the Error message OR a Screenshot?
Are you replicating SEPM version 11.x OR SEPM 12.1?
Is the AD integrated with SEPM?
Is the second SEPM, installed as additional site and are these both SEPM's carrying same version?
Check this Article:
Replication Fails with code error 0x80020000 on Symantec Endpoint Protection Manager
Hope that helps!!