Hi Thomas,
regarding your question: But how does the buffersize play into the whole thing?
Wish there is simple answer to this :-) The buffersize is mapped to the socket buffer size. Means it's OS and Automic Version depend. Means if you are on 12.x Automic then as much I can remember was the value for Windows 256KB. To rise the value more do not bring much benefits especially when there are many parallel FTs. For v21 do not have the values, but there is another logic (TLS) included where I'm not sure if the buffer size will change it much ? You have to try :-).
One hint for you, the File Transfer frames are limited to max. 32KB (now) ... At the moment the default is 1MB, this is nice when you run one FT in time ... But this looks different if you starts several transfers.
All of the previous values was related to Windows, if you're running on Unix it will be for sure different :-(
So long story short, "sometimes less is more".
BR p