You can try it and see how it goes. It won't impact the system if you have your polling set to 60s. Its very quick to grab all the metric QoS data it needs. Just activate it for a few minutes and collect a few polling samples. Make sure your QoS sampling is set to 1 so you grab metrics on each 60s poll.
In your example above I think it will combine all the QoS memory from each process that matches and graph it under that Profile's dataset. If you have Track PID turned on then it will break apart each matching process and create individual QoS targets for each process it matches against.