Do I need to upgrade the ESXi 4.1 hosts first?
- No - you could do this with the existing configuration, but the VM would be limited to running on just the ESXi 5 host. You would have to create a new datastore, present it to the ESXi 5 host and create a vmfs5 datastore.
Will upgrading convert the iSCSI VMFS-4 datastores to VMFS-5?
- No - upgrading is a manual step you perform on the datastore.
Will it hurt anything to have the VMFS-4 datastores presented an ESXi 5 host
- There's no problem doing this. If the VM stays at hardware version 7 you can run the VM on either ESXi 4 or 5. Once you upgrade the hardware version for the VM it can only run on the ESXi 5 host.
Just to clarify, physical RDM disks over 2TB are now supported in ESXi 5 - correct?
- Yes - physical RDMs and datastores can exceed 2 TB. Virtual disks and virtual RDMs are limited still to 2 TB.