Ciao
First what OS Guest mount the VM and what version of vSphere (ESXi and vCenter) you are using.
What type of network card are you using (VMXNET or E1000).
However, we have two possibilities to identify the problem, the first is a problem on a vSphere component (but perhaps the least likely), while the second is an application problem. From what I understand there is the roadrunner.exe could there be an Exchange server as a service on the machine?
I would proceed as follows:
1- Start the VM without a network card and always with the network card disconnected:
Check in the windows event viewer if there are any anomalous reports
Deactivate all the services concerning the applications (and stop any applications that start automatically)
2- Proceed to reconnect the network card and:
With all the applications stopped, Check if the VM crashes
Start one application at a time and check if the VM crashes