Depends on the use-case and you could solve this problem in many different ways -
1> Just use good old vlan-backed port-groups and route on an external device or virtual router of choice
2> Bank on the NSX capabilities in terms of workload mobility across Layer-3 boundaries by using vxlan backed PG's and hook'em up to DLR or ESG (latter won't give you distributed capabilities outside your host
So since this is an NSX forum , I'd bet the answer is "yes" , you want so solve your question by using DLR -
/r