Yes, but you would need to choose which one it would get...
you could do the first one
get-datastore |select-object -first 1
or a random
get-datastore | get-random
or one based on some type of filter
get-datastore | Where-object {$_.freespace -gt "5"}
This last one could still return multiple datastores depending on the filter you use....
How are you looking to choose just one?